EMT in cancer - Nature Reviews Cancer
网页2018年1月12日 · What roles does EMT have in cancer biology? Thomas Brabletz. Epithelial to mesenchymal transition (EMT) is executed by so-called EMT-activating transcription factors (EMT-TFs), mainly of...
Epithelial-Mesenchymal Transition in Cancer: A Historical …
网页2020年4月22日 · EMT in Cancer. In the early 80s, the correlation between EMT and cancer was reported. The benign tumor cells acquire infiltrating and metastasizing properties during the tumor progression due to EMT.
Epithelial–mesenchymal transition - Wikipedia
网页The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
The Epithelial-to-Mesenchymal Transition in Cancer - PMC
网页2018年2月16日 · In cancers, EMT inducers are hypoxia, cytokines, and growth factors secreted by the tumor microenvironment, stroma crosstalk, metabolic changes, innate and adaptive immune responses, and treatment with antitumor drugs.
New insights into the mechanisms of epithelial–mesenchymal transition ...
网页2018年11月20日 · Epithelial–mesenchymal transition (EMT) is crucial for embryogenesis, wound healing and cancer development, and confers greater resistance to cancer therapies.
How important is EMT for cancer metastasis? | PLOS Biology
网页2024年2月7日 · Epithelial-to-mesenchymal transition (EMT) is an embryonic gene program aberrantly activated during cancer progression that facilitates tumor cell detachment from epithelial tissue and subsequent dissemination and metastasis [1].
The Epithelial-to-Mesenchymal Transition (EMT) in Development and Cancer
网页We go on to describe how EMT regulators participate in the progression of pancreatic and breast cancer in mouse models, and discuss the parallels with developmental EMTs and how these help to understand cancer EMTs.
Guidelines and definitions for research on epithelial–mesenchymal ...
网页2020年4月16日 · Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and...
The molecular mechanisms and therapeutic strategies of EMT in …
网页2022年9月8日 · Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis, including promoted migration and invasiveness, increased tumor stemness, …
Novel therapeutic strategies: targeting epithelial–mesenchymal ...
网页In colorectal cancer, EMT has an important role in tumour progression, metastasis, and drug resistance. There has been accumulating evidence from preclinical and early clinical studies that show that EMT markers might serve as outcome predictors and potential therapeutic targets in colorectal cancer.
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