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The EMBO Journal
16 天
Cellular senescence, p21, and the path to fibrosis
In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...
澎湃新闻
19 天
中国科学技术大学魏海明团队:揭示p53调节肿瘤免疫微环境的潜在机制
并表明阻断IL-34信号是携带p53突变的肿瘤患者的潜在免疫疗法。 团队发现CT细胞(Trp53)和AML12细胞(小鼠肝细胞系)中Trp53的基因缺失,导致在用Nutlin-3预处理细胞后,无法增加p21表达。Trp53的基因缺失,导致IL-34的表达上调。相比之下,在PT细胞中过表达Trp53时 ...
生物谷
22 天
Commun Chem:新研究揭示突变的p53 蛋白促进p63和p73转化为癌症促进因子 ...
正常的p53可以形成功能性生物分子凝聚物,而这些突变体则大大加快了向固态、淀粉样状态的转变。这种转变通过一种类似朊病毒(prion)的机制 ...
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今日热点
Shot multiple times in Vegas
Campaign denies plagiarism
California college shooting
Grants honorable discharges
Revives Fox News lawsuit
Trump Media stock plunges
Settles wrongful death suit
Secret Service blamed
Testifies before Congress
People still missing in NC
Ownership stake approved
Out of disaster loan money
SCOTUS rejects appeal
Holiday sales to rise?
To close 1,200 US stores
Scales back discounts
Entity designated terrorists
Robinson sues CNN
GA hand-count rule blocked
Must face US state lawsuits
Second venue in Abu Dhabi
PA gun restrictions ruling
Giant pandas arrive in US
USDA launches probe
$750M US chips grant
US crude prices fall
Revives journalist's case
Might limit counterstrike
Broadband data caps probe
Holds rally in Georgia
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