To test the effects of FAD mutations on the stability of these enzyme-substrate complexes ... where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid ...
Several mutations affecting β-amyloid, either to APP 1,2,3 ... On each individual test, transgenic mice were always compared to littermate controls so that age and background strain were comparable.
In the Journal of Clinical Investigation, January 2, scientists led by Zhifang Dong at the Children’s Hospital of Chongqing Medical University, China, report that lactate modifies specific lysines on ...
Other signs of Alzheimer’s, such as brain shrinkage and tangles of a second abnormal protein ... amyloid drugs might be better suited to prevention than treatment. An obvious way to test this ...