In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...

并表明阻断IL-34信号是携带p53突变的肿瘤患者的潜在免疫疗法。 团队发现CT细胞（Trp53）和AML12细胞（小鼠肝细胞系）中Trp53的基因缺失，导致在用Nutlin-3预处理细胞后，无法增加p21表达。Trp53的基因缺失，导致IL-34的表达上调。相比之下，在PT细胞中过表达Trp53时 ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

研究显示，补充3个月的番茄红素，能延缓小鼠大脑衰老，并缓解年龄相关的认知损伤，番茄红素改善了衰老小鼠的神经元退化、线粒体功能障碍、突触损伤，并促进了突触囊泡融合。

Stroke is a common disease in clinical practice, which seriously endangers people’s physical and mental health. The neurovascular unit (NVU) plays a key role in the occurrence and development of ...

The new version of kartcom.com can be viewed easily on all platforms. At the forefront of web technologies, the functionality of version 2 has been greatly extended to facilitate the organisation of ...

正常的p53可以形成功能性生物分子凝聚物，而这些突变体则大大加快了向固态、淀粉样状态的转变。这种转变通过一种类似朊病毒（prion）的机制 ...

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