The primary antibodies used, including P65, p-IκBα, IκBα, Pi3k, Akt, p-Pi3k, p-Akt, p38, caspase-3, cleaved caspase-3, Bax, Bcl-2, P53 and the loading control antibody β-actin levels were performed ...

We discovered that Drice is, as an inactive proform, primarily proximal to cell membrane proteins, including cell adhesion molecule Fasciclin 3 (Fas3). Notably, Drice is proximal to the specific ...

In particular, they had to engineer a new reporter by which non-lethal caspase activation could be detected. The authors conducted a proximity labeling experiment and identified Fasciclin 3 as a key ...

Malfunction of the p53 pathway is an almost universal hallmark of human tumours. [1,2] Somatic mutation of TP53 that results in the absence or dysfunction of p53 is one of the most common ...

1 Graduate School, China Academy of Chinese Medical Sciences, Beijing, China 2 Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China Ferroptosis is a recently identified form of ...