To test the effects of FAD mutations on the stability of these enzyme-substrate complexes ... where it is these enzyme-substrate complexes that trigger neurodegeneration even in the absence of amyloid ...
Several mutations affecting β-amyloid, either to APP 1,2,3 ... On each individual test, transgenic mice were always compared to littermate controls so that age and background strain were comparable.
Department of Medicinal Chemistry, University of Kansas, Lawrence, United States Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard ...
In the Journal of Clinical Investigation, January 2, scientists led by Zhifang Dong at the Children’s Hospital of Chongqing Medical University, China, report that lactate modifies specific lysines on ...
A common cognitive disorder with symptoms that mimic Alzheimer's is often mistaken for the disease. Researchers are calling for criteria to diagnose the little-known condition.