The three-dimensional shape of a protein can be used to resolve deep, ancient evolutionary relationships in the tree of life, ...

AlphaFold solved a structural biology riddle: predicting protein structure. And yet, CASP, a global competition born to solve that problem, lives on.

In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...

Federal science agencies have renewed and increased funding for a world-renowned digital archive of protein structures housed ...

Along with greater accuracy for the prediction of 3D protein structures ... “Experimental protein-structure prediction can take about the length of a PhD and cost hundreds of thousands of ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Proteins have four levels of structure: primary (amino acid sequence), secondary (local folding patterns like alpha helices and beta sheets), tertiary (overall 3D shape), and quaternary (assembly of ...

In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, ...

No large RNA structure database exists that correlates sequence with 3D topology. Successful protein-centric methods like AlphaFold remain unavailable for RNA, creating a critical gap in ...