研究显示，仅4个月的藏红花素治疗，可以提高老年小鼠细胞能量水平，显著改善了记忆力、探索性行为、协调性，并提高了大脑、心脏等重要器官中ATP和NAD + 水平，延缓了大脑衰老，并使平均寿命延长17.7%。

慢性肾脏病（CKD）是全球日益严重的公共卫生问题，全球范围内CKD的患病率已达到10%以上。预计到2050年，CKD将成为全球第5大死因。然而，无论CKD患者的病因如何（糖尿病、高血压、自身免疫性疾病等），肾小管间质和肾小球均会出现纤维化，是肾功能丧 ...

Creatine kinase M2 (CKMT2) plays a key role in mitochondrial dysfunction in type 2 diabetes, affecting energy metabolism in ...

研究人员确定了细胞核和mtDNA编码亚基的OXPHOS复合体的正确化学计量组装机制。 近日，一篇发表在国际杂志Cell Metabolism上题为“Misregulation of ...

Tumor cells were classified into three metabolic states: OXPHOS+, OXPHOS-, and PPP+, with PPP+ cells showing increased proliferation, CD44 positivity, and a higher resistance to PD-1 blockade.

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team ...

They assessed mitochondrial adenosine triphosphate (ATP) generation capability by analyzing oxidative phosphorylation (OXPHOS ...