The recent findings of Waldo et al. 1 demonstrate that the fusion of the green fluorescent protein (GFP) to insoluble proteins dramatically reduces its folding ability in prokaryotic cells.

Avoid fusions to the GFP fragments at the site of protein-protein interaction and consider optimizing the spacer length between the fusions and GFP fragments, if necessary. In the absence of ...

A startup founded by former Meta researchers is creating an alternative evolutionary path using the most powerful ...

In this important manuscript, the authors provide evidence for this mechanism in two different mechanically gated channels. The experiments were carried out in the same membranes, but the evidence is ...

A team of researchers designed AI model capable of generating new proteins, trained on a simulation of 500 million years of ...

The model was able to predict optimized GFP sequences that had as many as seven different amino acids from the protein sequence they started with, and the best of these proteins were estimated to ...

I have a clear memory of presenting my initial results about a “failed” protein at a lab meeting with my postdoctoral advisor Angus Lamond at the University of Dundee in Scotland and the rest of his ...

Researchers discover how Zika virus and related viruses replicate in human cells, illuminating potential new vaccines.