Topol pioneered the development of many routinely used medications, including tissue plasminogen activator, clopidogrel (Plavix), bivalirudin (Angiomax), and abciximab (ReoPro), and was the first ...

The Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial showed that the direct thrombin inhibitor bivalirudin, with provisional glycoprotein (Gp) IIb/IIIa ...

After more than 70 years of effective clinical use, heparin remains the most common anticoagulant in use and one of the most commonly prescribed drugs to hospitalized patients. However, the ...

He has pioneered the development of many medications that are routinely used in medical practice including t-PA, Plavix, Angiomax and ReoPro and was the first physician to raise safety concerns on ...