TRPV3 enhances skin keratinocyte proliferation through EGFR …
Mechanistic investigation demonstrated that carvacrol stimulated TGFα release and increased phosphorylation levels of EGFR, PI3K, and NF-κB, effects abolished by suppression of TRPV3 …
EGFR inhibitors switch keratinocytes from a proliferative to a ...
2021年1月5日 · EGFRi directly affect basal keratinocyte growth, leading to tissue size reduction and switching keratinocytes from a proliferative to a differentiative phenotype, as evidenced by …
EGFR Regulates the Expression of Keratinocyte-Derived …
In cultured human keratinocytes, proinflammatory cytokines synergized with TGF-α to induce GM-CSF expression. Accordingly, high epidermal levels of EGFR activation are associated with …
Mechanisms underlying skin disorders induced by EGFR inhibitors
2015年6月1日 · Here, we summarize current literature on the molecular and cellular mechanisms underlying the cutaneous side effects induced by EGFR inhibitors and provide evidence that …
Topical JAK inhibition ameliorates EGFR inhibitor–induced rash in ...
2024年6月19日 · Mechanistically, the induction of S100 calcium-binding protein A9 (S100A9) occurred before skin barrier disruption and led to keratinocyte activation, resulting in …
EGFR inhibitors switch keratinocytes from a proliferative to a ...
2021年1月5日 · Results: EGFRi directly affect basal keratinocyte growth, leading to tissue size reduction and switching keratinocytes from a proliferative to a differentiative phenotype, as …
EGFR regulation of epidermal barrier function - PMC
2012年4月4日 · Epidermal growth factor receptor (EGFR) regulates multiple keratinocyte functions including proliferation, adhesion and migration, survival, and differentiation (27, 45, …
The EGF receptor ligand amphiregulin controls cell division
2015年8月3日 · Keratinocyte differentiation is strongly influenced by extracellular calcium concentration 59 and inhibition of EGFR tyrosine kinase activity 60 and we found a significant …
TRPV3 enhances skin keratinocyte proliferation through EGFR
2020年6月13日 · To determine if PI3K and NF-κB mediate EGFR-induced keratinocyte proliferation in response to TRPV3 activation, we assessed their activity levels by using the …
(PDF) TRPV3 enhances skin keratinocyte proliferation through EGFR ...
2021年4月1日 · Mechanistic investigation demonstrated that carvacrol stimulated TGFα release and increased phosphorylation levels of EGFR, PI3K, and NF-κB, effects abolished by …