Topotecan Injection is indicated for the treatment of chemotherapy-sensitive small cell lung cancer (SCLC) after failure of first-line chemotherapy. Chemotherapy-sensitive SCLC is defined...
Topotecan | C23H23N3O5 | CID 60700 - PubChem
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.
Topotecan - Wikipedia
Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types.
Topotecan (intravenous route) - Mayo Clinic
Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. This medicine is also used to treat a certain type of lung cancer called small cell lung cancer.
Topotecan in combination with cisplatin is indicated for patients with carcinoma of the cervix recurrent after radiotherapy and for patients with Stage IVB disease. Patients with prior exposure to cisplatin require a sustained treatment free interval to justify treatment with the combination (see section 5.1).
托泊替康 - 百度百科
拓扑替康（Topotecan）为喜树碱半合成衍生物，是一种抑制拓扑异构酶Ⅰ的药物，能与拓扑异构酶Ⅰ-DNA复合物结合，从而阻碍断裂DNA单链的重新链接。 形成的拓扑替康-拓扑异构酶Ⅰ-DNA三元复合物与复制酶相互作用，造成双链DNA的损伤。
Initial dose The recommended dose of topotecan is 1.5 mg/m2 body surface area per day administered by intravenous infusion over 30 minutes daily for five consecutive days with a three-week interval between the start of each course. If well tolerated, treatment may continue until disease progression (see sections 4.8 and 5.1).
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2726 - Pfizer
Topotecan Hydrochloride for Injection. small cell lung cancer sensitive disease after failure of first-line chemotherapy. (1) combination therapy with cisplatin for stage IV-B, recurrent, or persistent carcinoma of the cervix which is not amenable to curative treatment with surgery and/or radiation therapy. (1) 4- mg (free base) single-dose vial.
Topotecan: An Oncologist's View | The Oncologist - Oxford …
1998年12月1日 · Topotecan stabilizes the covalent intermediate between topoisomerase I and DNA, the “cleavable complex;” it inhibits topoisomerase I and causes single-strand DNA breaks which inhibit DNA function and lead ultimately to cell death by generating double-stranded DNA breaks when DNA replication occurs [ 4 ].
Topotecan for Relapsed Small-cell Lung Cancer: Systematic …
2015年10月21日 · Topotecan is the most reliable chemotherapy regimen for relapsed small-cell lung carcinoma (SCLC). The efficacy and adverse effects of topotecan as reported by previous studies varied greatly. The inclusion criterion was a prospective study that was able to provide data for 6-month over-all survival …