TNF受体超家族成员GITR共刺激免疫检查点分子 - 知乎
基因功能简介. TNFRSF18（TNF受体超家族成员18）也称为糖皮质激素诱导的TNFR相关蛋白（GITR），其在包括T细胞在内的许多免疫细胞上表达。. 作为T细胞的共同刺激信号，TNFRSF18在T细胞活化后被上调，进而促进T细胞增殖。. 已知CD25+/CD4+调节性T细胞可介导 …
Induction of Antigen-Independent Proliferation of Regulatory T-Cells …
TNF receptor superfamily comprises many T-cell costimulatory receptors, including TNFRSF1, TNFRSF2, TNFRSF4 (OX40), TNFRSF9 (4-1BB), TNFRSF18 (GITR), and TNFRSF7 (CD27). Signaling through these costimulatory stimulatory receptors can promote conventional T-cell (Tconv) proliferation, and effector functions in an antigen-dependent manner.
TNFRSF18 Gene - GeneCards | TNR18 Protein | TNR18 Antibody
2024年10月2日 · This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T …
Multidirectional characterization of cellular composition and …
2023年7月25日 · Moreover, a cell surface receptor−TNFRSF18/GITR was highly expressed in T cells of MPLCs, suggesting TNFRSF18 as one potential immunotherapeutic target in MPLCs.
Antibody-Targeted TNFRSF Activation for Cancer Immunotherapy: …
2022年7月5日 · TNFRSF signaling stimulates the activation, proliferation of various immune cells, including myeloid cells and T cells, providing potential targets for cancer immunotherapy application. However, TNFRSF agonistic antibodies have shown limited success in the clinic, which may be due to limited receptor clustering-mediated signaling or associated ...
The Role of GITR/GITRL Interaction in Autoimmune Diseases
2020年10月8日 · Glucocorticoid-induced TNFR related protein (GITR, also known as TNFRSF18) is a member of the TNFR superfamily, which is expressed on regulatory T cells (Tregs) and some activated immune cells, including effector T lymphocytes, nature killer (NK) cells, and neutrophils (1–4).
The transcription factor NFIL3 controls regulatory T-cell
2019年7月16日 · Overexpression of Nfil3 in Treg cells led to diminished expression of Foxp3 and other signature Treg genes, including Il2ra, Icos, Tnfrsf18, and Ctla4. Furthermore, Nfil3 -overexpressing Treg...
Glucocorticoid-Induced TNF Receptor Family-Related Protein ... - PubMed
2014年2月3日 · Glucocorticoid-induced tumor necrosis factor receptor family-related protein (TNFRSF18, CD357) is constitutively expressed on regulatory T cells (Tregs) and is inducible on effector T cells. In this report, we examine the role of glucocorticoid-induced TNF receptor family-related protein ligand (GITR-L), which is expressed by antigen presenting ...
Tumor necrosis factor receptor family costimulation increases ...
2020年2月3日 · Enrichment analysis of genes up-regulated by TNFR2 agonist (FDR < 0.05, Log2FC > 0.5) showed that the “NF-κB signaling pathway” and “T-cell activation” pathway were among the most significantly represented (Fig. 2E). Also, genes of the “TNF signaling via NF-κB” pathway were upregulated by TNFR2 agonist in Tregs (Fig. 2F).
Glucocorticoid-induced tumor necrosis factor receptor family …
Background & aims: The glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR; also called TNFRSF18 or CD357) regulates the T cell-mediated immune response and is present on surfaces of regulatory T (Treg) cells and activated CD4(+) T cells. We investigated the roles of GITR in the development of colitis in mice.