Modeling pancreatic cancer in mice for experimental therapeutics
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical evaluation of various therapeutic modalities.
Modeling pancreatic cancer in mice for experimental therapeutics
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical e …
Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model
KRAS mutations are observed in 80–90% of all human PDACs with mutations in TP53 detected in 50–75% of PDACs. As a result, one of the most studied genetically engineered mouse models of PDAC incorporates mutations in Kras and Trp53 that are targeted specifically to the mouse pancreas using Cre-Lox technology (Hingorani et al., 2005).
Bioengineered 3D models of human pancreatic cancer ... - Nature
2021年9月24日 · Here, the authors show how self-assembled patient-derived models of pancreatic cancer recapitulate key biological features of the original tumours such as matrix composition and stemness.
Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer
2024年9月14日 · Novel preclinical pancreatic cancer (PC) models were established via 3D bioprinting (3DP). PC 3DP model maintains high-fidelity histological and genomic characteristics. Significant heterogeneity was observed in PC 3DP models chemotherapy drug testing in vitro. A correlation exists between PC 3DP model drug sensitivity and actual clinical outcomes.
Animal models for modeling pancreatic cancer and novel drug ... - PubMed
Suitable small animal models are a prerequisite for better understanding of underlying pathophysiology and for translational studies designed to uncover novel therapeutic targets and to evaluate therapy regimens on a preclinical level.
Development of human pancreatic cancer avatars as a model for …
2024年7月5日 · Here, we show how a personalized organotypic “avatar” created from resected tissue allows spatial and temporal reporting on a complete in situ tumor microenvironment and mirrors clinical responses.
Establishment of a pancreatic cancer animal model using the …
2022年6月14日 · In this study, Kamimura and colleagues describe pancreas-targeted hydrodynamic gene delivery of human pancreatic cancer-related genes to develop an easy-to-use, reproducible animal model of pancreatic cancer in wild-type rats.
Characterization of genetic subclonal evolution in pancreatic cancer ...
2019年11月28日 · Here we report evidence of continuing subclonal evolution after tumor initiation that largely reflect copy number alterations that target cellular processes of established significance in human...
In vivo models of pancreatic ductal adenocarcinoma
2023年1月1日 · In this review, we highlight evolution of in vivo models for PDAC including spontaneous tumors models (i.e., chemical induction, genetic modification, viral delivery), implantation models including patient derived xenografts (PDX), and humanized PDX.