PD-1 and PD-L1 inhibitors - Wikipedia
PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of …
Immune Checkpoint Inhibitors - NCI - National Cancer Institute
Blocking the binding of PD-L1 to PD-1 with an immune checkpoint inhibitor (anti-PD-L1 or anti-PD-1) allows the T cells to kill tumor cells (right panel). How do immune checkpoint inhibitors …
Immune Checkpoint Inhibitors and Their Side Effects
Both PD-1 and PD-L1 inhibitors have been shown to be helpful in treating many different types of cancer. CTLA-4 is another checkpoint protein on some T cells that acts as a type of “off …
Anti-PD-1 and PD-L1 monoclonal antibodies (immune checkpoint inhibitors)
2023年6月22日 · Anti-PD-1 and PD-L1 monoclonal antibodies are a type of targeted immunotherapy called an immune checkpoint inhibitor. Checkpoint inhibitors don't kill cancer …
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy
2021年9月1日 · The inhibitors of PD1/PDL1 have shown clinical efficacy in many tumors, for example, blockade of PD1 or PDL1 with specific antibodies enhances T cell responses and …
Clinical efficacy and safety of anti-PD-1/PD-L1 inhibitors for the ...
2020年2月7日 · Anti-PD-1/PD-L1 inhibitors were identified as a preferable treatment option for advanced or metastatic cancer patients who are male, aged < 65 years, current or former...
PD-1/PD-L1 immune checkpoint inhibitors in the treatment of ...
2024年10月31日 · Triple negative breast cancer (TNBC) represents a particularly aggressive and clinically challenging subtype of breast cancer, characterized by its invasive nature and …
Small molecule inhibitors targeting the PD-1/PD-L1 signaling …
2020年3月9日 · In this review, we summarized a number of small molecule inhibitors based on three different therapeutic approaches interfering PD-1/PD-L1 signaling pathway: (1) blocking …
Regulatory mechanisms of PD-1/PD-L1 in cancers - Molecular …
2024年5月18日 · Anti-PD-1/PD-L1 inhibitors have become effective immune checkpoint inhibitors (ICIs) and are rapidly becoming the standard therapy for various cancers. Tumor …
Advances in pharmacokinetics and pharmacodynamics of PD-1/PD-L1 inhibitors
2023年2月1日 · PD-1/PD-L1 immune checkpoint inhibitors block tumor-related downregulation of the immune system, thereby enhancing antitumor immunity. In comparison with traditional …