Cardiac Metabolism in Heart Failure | Circulation Research
2013年8月30日 · Characterizing cardiac metabolism in heart failure (HF) revealed several metabolic alterations called metabolic remodeling, ranging from changes in substrate use to mitochondrial dysfunction, ultimately resulting in ATP deficiency and impaired contractility.
Metabolic mechanisms in physiological and pathological cardiac ...
2023年5月26日 · In this Review, Ritterhoff and Tian describe the metabolic reprogramming that occurs in cardiac hypertrophy and heart failure; discuss the contribution of metabolism to energy-generating...
Cardiac Energy Metabolism in Heart Failure | Circulation Research
2021年5月14日 · Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart failure are complex and are dependent not only on the severity and type of heart failure present but also on the co-existence of common comorbidities such as obesity and type 2 diabetes.
Metabolic remodelling in heart failure - Nature
2018年6月18日 · In this Review, Bertero and Maack describe the physiological processes of cardiac energy metabolism and their pathological alterations in heart failure and diabetes mellitus, and discuss...
Cardiac Energy Metabolism in Heart Failure - PubMed
2021年5月14日 · Of importance, pharmacological targeting of the energy metabolic pathways has emerged as a novel therapeutic approach to improving cardiac efficiency, decreasing the energy deficit and improving cardiac function in the failing heart.
Glucose Metabolism in Cardiac Hypertrophy and Heart Failure
2019年6月12日 · Patients surviving myocardial infarction (MI) may undergo extensive pathological remodeling in the heart with major metabolic derangements. Here, we review recent findings of cardiac metabolic changes in response to hemodynamic stress and cardiac ischemia with a focus on glucose utilization.
Metabolomics and Cardiovascular Risk in Patients with Heart Failure…
2024年5月23日 · The associations of plasma metabolites with adverse cardiovascular (CV) outcomes are still underexplored and may be useful in CV risk stratification. We performed a systematic review and meta-analysis to establish correlations between blood metabolites and adverse CV outcomes in patients with heart failure (HF).
Metabolic disorder in the progression of heart failure - PubMed
Heart failure (HF) is a major clinical concern owing to its high prevalence and high mortality. Metabolomics, an effective approach to predict diagnostic biomarkers and to explore the altered metabolic pathways in pathogenesis, has been extensively …
Metabolic Flexibility of the Heart: The Role of Fatty Acid Metabolism …
2024年1月19日 · In the subsequent sections, this review delves into the leading role of FA metabolism, specifically in the heart, particularly under the influence of widespread cardiovascular pathologies, including heart failure and diabetic cardiomyopathy, offering a comprehensive analysis of its impact and implications in these prevalent conditions.
Deciphering metabolic remodeling of the failing hearts
2022年8月29日 · A landscape view of metabolic remodeling in end-stage human failing hearts generated by multiomics analysis confirms main changes in cardiac energy metabolism and challenges several widely held...