Mouse models for lung cancer - PMC - PubMed Central (PMC)
In this review we will describe mouse models of lung cancer and how they are used to better understand the disease and how they are exploited to develop better intervention strategies. Keywords: Lung cancer, Mouse models, Experimental model systems. 1. Introduction. Lung cancer is the leading cause of cancer deaths worldwide.
Mouse models for lung cancer - ScienceDirect
2013年4月1日 · In this review we will describe mouse models of lung cancer and how they are used to better understand the disease and how they are exploited to develop better intervention strategies.
A mouse model of lung cancer induced via intranasal injection …
Mouse models of lung cancer consist of three major types: spontaneous models, drug‐induced models, and lung cancer cell‐injected models. A/J mice are widely used as a spontaneous model associated with developing pulmonary cancer with age [7].
Genetically-engineered mouse models of small cell lung cancer
2024年1月8日 · Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in dire need of new and effective therapeutic approaches. Modeling SCLC in an immunocompetent host is...
Genetically-engineered mouse models of small cell lung cancer
Human SCLC is characterized by near universal genetic loss of the RB1 and TP53 tumor suppressor genes. Twenty years ago, the first genetically-engineered mouse model (GEMM) of SCLC was generated using conditional deletion of both Rb1 and Trp53 in the lungs of adult mice.
A Lung Cancer Mouse Model Database - PMC - National Center …
2024年2月28日 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model.
A Lung Cancer Mouse Model Database - bioRxiv
2024年5月14日 · Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets covering 974 samples from genetically engineered mouse models (GEMMs), 368 samples from carcinogen-induced models, and 12 samples from a spontaneous model.
Mouse models for human lung cancer - Genes & Development
In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC).
Mouse models of lung cancer - PubMed
2006年7月15日 · The mouse is a promising model system, as complex human genetic traits causal to lung cancer, from inherited polymorphisms to somatic mutations, can be recapitulated in its genome via genetic manipulation.
Characterization of a genetic mouse model of lung cancer: a …
This mouse model develops lung adenocarcinomas with a high incidence of metastases and gender differences in cancer-related death. The use of our pipeline in the framework of metastatic lung cancer model, combined with the power of RNA-seq technology, allowed the identification of ADORA3 as new putative target for antibody-based therapy in ...
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