MicroRNA‐146a represses LRP2 translation and leads to cell apoptosis …
2016年5月31日 · As caspase-3 cleavage and annexin V propidium iodide detection indicates apoptosis, our results imply that Lrp2 is a potent protector of SH-SY5Y cells, guarding against Aβ-induced apoptosis. Further, activation of the Akt signaling pathway has previously been shown to prevent Aβ-induced neuronal death [ 47 , 48 ] .
MicroRNA-146a represses LRP2 translation and leads to cell apoptosis …
Overexpression of miRNA-146a in SH-SY5Y cells significantly decreased Lrp2 expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby increasing cell apoptosis. Thus, specific miRNA-146a regulation may contribute to AD by downregulating the Lrp2/Akt pathway. Keywords: Alzheimer's disease; Lrp2 ...
MicroRNA-146a inhibition promotes total neurite outgrowth and ...
2021年3月15日 · Another study, based on human neuroblastoma SH-SY5Y cells, reveals that miR-146a inhibits Lrp2 protein expression and reduces subsequent Akt activation as well as pro-apoptotic caspases-3 induction, which ultimately elevates cell apoptosis in AD .
LRP-1/LRP-2 roles in AD - National Center for Biotechnology …
2012年7月16日 · LRP2 is acting as an apical SHH-binding protein that sequesters SHH in its target field and controls internalization and cellular trafficking of SHH/patched 1 complexes (Christ et al., 2012). In the brain, LRP2 participates in endocytosis and internalization of ApoE, APP and Aβ peptide (LaFerla et al., 1997).
2016年2月22日 · In this study, we aimed to explore whether Lrp2 is a target of miRNA-146a, and found that downregula-tion of Lrp2 by miRNA-146a is mediated through translational repression, rendering cells more suscepti-ble to apoptosis. Our findings provide insight into a novel signaling pathway that hinders the beneficial effects of normal Lrp2 metabolism ...
Ribosome stalling during selenoprotein translation exposes a ...
2022年5月30日 · In this study, we discover that the lipoprotein receptor LRP8 (also known as ApoER2) promotes ferroptosis resistance in cancer. Mechanistically, LRP8 affects ferroptosis by regulating selenium ...
Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 …
2020年1月6日 · Metformin treatment suppresses the proliferative ability and induces apoptosis of TPC-1 cells by downregulating LRP2 to block the JNK pathway. Keywords: metformin, LRP2, JNK, proliferation Introduction
Immune-mediated tubule atrophy promotes acute kidney injury to …
2022年8月19日 · TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
Melanoma tumors frequently acquire LRP2/megalin expression…
Megalin-encoding mRNA is frequently detected in melanoma primary tumors and melanoma metastases. We investigated the expression of LRP2 (megalin-encoding) mRNA in a panel of formalin-fixed, paraffin-embedded patient samples including nevi, …
Metformin Inhibits Proliferation of Human Thyroid Cancer …
2020年1月6日 · Metformin treatment suppresses the proliferative ability and induces apoptosis of TPC-1 cells by downregulating LRP2 to block the JNK pathway.
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