Insulin receptor - Wikipedia
The insulin receptor is a type of tyrosine kinase receptor, in which the binding of an agonistic ligand triggers autophosphorylation of the tyrosine residues, with each subunit phosphorylating its partner.
The Insulin Receptor and Its Signal Transduction Network
2016年4月27日 · Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting through a receptor located in the membrane of target cells - major ones being liver (where it promotes glucose storage into glycogen and decreases glucose output), as well as skeletal muscle and fat (where it stimulates glucose transport through translocation o...
Understanding insulin and its receptor from their three …
The insulin receptor’s three-dimensional structure. Insulin's role in promoting glucose transport across cell membranes was discovered in 1949 [67], and an insulin-binding fraction of rat liver membrane was first isolated in 1970 [68], establishing that insulin acted via a …
Biochemical and cellular properties of insulin receptor signalling
2017年10月4日 · The three major biochemical steps in insulin signalling are: tyrosine phosphorylation of the receptor and its direct substrates; activation of the lipid kinase, PI3K; and activation of multiple...
The insulin receptor: structure, function, and signaling - PubMed
The insulin receptor is a member of the ligand-activated receptor and tyrosine kinase family of transmembrane signaling proteins that collectively are fundamentally important regulators of cell differentiation, growth, and metabolism.
Mechanisms of Insulin Action and Insulin Resistance - PMC
In this review, we focus on physiological effects of mammalian insulin binding to the insulin receptor and molecular mechanisms by which insulin’s effects are attenuated in the insulin-resistant state that heralds and accompanies T2D.
Structure of the insulin receptor–insulin complex by single …
2018年2月28日 · The insulin receptor is a dimeric protein that has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain...
The insulin receptor: structure, function, and signaling
1994年2月1日 · The insulin receptor is a member of the ligand-activated receptor and tyrosine kinase family of transmembrane signaling proteins that collectively are fundamentally important regulators of cell differentiation, growth, and metabolism.
The Activation Mechanism of the Insulin Receptor: A Structural ...
2023年6月20日 · The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human diseases, such as diabetes and cancers.
Insulin Receptor Signaling in Health and Disease - PMC
The insulin receptor (IR) is now better recognized as the signaling protein that regulates metabolism through cell differentiation and growth. Following IR-β kinase activity, the downstream effects of this signaling paradigm are vital for the glucose homeostasis of many cell types.