IFNγ: signalling, epigenetics and roles in immunity ... - Nature
2018年6月19日 · Signalling by the IFNγ receptor activates the Janus kinase (JAK)–signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of …
Regulation of type I interferon responses - Nature
2013年12月23日 · Type I IFNs activate the IFN-stimulated gene factor 3 (ISGF3) complex, which is comprised of STAT1, STAT2 and IFN-regulatory factor 9 (IRF9); the ISGF3 complex binds …
IFNAR1 and IFNAR2 play distinct roles in initiating type I ... - AAAS
2021年11月23日 · Type I interferons form a complex with the receptor subunits IFNAR1 and IFNAR2, which stimulates cross-activation of the tyrosine kinases associated with the receptor …
IFNγ induces PD-L1 overexpression by JAK2/STAT1/IRF-1
2017年12月19日 · To determine whether IFNγ-induced PD-L1 overexpression is mediated by activation of JAK2/STAT1/IRF-1 signaling, we investigated PD-L1 promoter activities and …
Targeting IFN/STAT1 Pathway as a Promising Strategy to …
The interferon (IFN)-mediated activation of the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling is crucial for cell sensitivity to ionizing radiation. Several …
Frontiers | Interferon Receptor Trafficking and Signaling: Journey …
2021年1月19日 · During acute brain infection by the simian immunodeficiency virus (SIV), IFN-α signaling is drastically hampered with a down-regulation of downstream effectors such as …
Stat1-dependent and -independent pathways in IFN-γ-dependent …
2002年2月1日 · Stat1-independent pathways provide the host with a redundant fail-safe mechanism for antiviral responses. A partially dominant germline mutation in human Stat1, …
Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives ...
Absence of Ifngr1 or Stat1 completely blocked the development of Ifn-γ induced midbrain calcinosis phenotype and nigrostriatal neurodegeneration phenotype. This implies that the …
Molecular pathways: interferon/stat1 pathway: role in the …
2012年6月1日 · Although the activation of STAT1 by IFNs is classically associated with antiviral defense and tumor-suppressive functions, emerging data indicate that expression of the …
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 …
2018年12月17日 · Overexpression of IFNAR1, MX1 and signal transducer and activator of transcription 1 (Stat1) indicated the endogenous IFNα activation in tumour microenvironment, …