Interferon gamma - Wikipedia
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin , and by others as a ...
IFNγ: signalling, epigenetics and roles in immunity ...
2018年6月19日 · IFNγ is a cytokine that is primarily produced by cells of the immune system, including innate-like lymphocyte populations, such as natural killer (NK) cells and innate lymphoid cells (ILCs),...
IFNγ: signalling, epigenetics and roles in immunity,
Signalling by the IFNγ receptor activates the Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) pathway to induce the expression of classical interferon-stimulated genes that have key immune effector functions.
IFN-γ: A cytokine at the right time, is in the right place - PMC
IFN-gamma biology. Following its discovery in 1965 as a soluble antiviral factor released by phytohemagglutinin-stimulated PBMC [23], Interferon gamma (IFN-γ) became well known for its pleiotropic immunomodulatory effects on both innate and adaptive immunity.
Interferon-gamma: an overview of signals, mechanisms and functions
Interferon-gamma (IFN-gamma) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-gamma ligand, receptor, signal transduction, and cellular effects with a focus on macrophage respo ….
Interferon-γ: an overview of signals, mechanisms and functions
2003年10月2日 · This article reviews the current understanding of IFN-γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection.
Interferon Gamma - an overview | ScienceDirect Topics
Interferon-γ (IFN-γ) is an important cytokine that is found in decreased amounts in patients with IPF. IFN-γ is produced by NK and T cells and is an important antiviral cytokine and activator of macrophages.
Interferon-gamma (IFN-γ): Reviewing its mechanisms and
Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and regulates cellular apoptosis and proliferation.
Interferon-gamma (IFN-γ): Reviewing its mechanisms and ...
2023年6月1日 · Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in mediating an array of immune responses including promotes antiviral activity, facilitates macrophage activation, controls Th1/Th2 balance, and …
Interferon- γ and infectious diseases: Lessons and prospects - AAAS
In response to infection, a small protein called interferon-γ (IFN-γ) is synthesized and released by several types of cells belonging to the immune system. IFN-γ acts on both immune and nonimmune cells to provide protection against bacteria, parasites, and fungi.