EGR1 - Wikipedia
EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor .
EGR1 Gene - GeneCards | EGR1 Protein | EGR1 Antibody
2024年10月1日 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia . Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling .
Early Growth Response‐1, an Integrative Sensor in Cardiovascular and ...
2021年11月10日 · Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders.
Egr1 regulates regenerative senescence and cardiac repair
2024年6月14日 · We identified early growth response protein 1 (Egr1) as a regulator of regenerative senescence in both models. In the neonatal heart, Egr1 facilitates angiogenesis and cardiomyocyte...
The Role of the Transcription Factor EGR1 in Cancer
The EGR1 gene is located in human chromosomal region 5q23-31, and the protein is an important transcription factor (1), which contains an activation regulatory region, repressive regulatory region, and three Cys2-His2 subclass zinc finger structures, which specifically recognize and bind target genes and regulate their transcription.
EGR1 is a gatekeeper of inflammatory enhancers in human …
2021年1月13日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.
EGR1 protein expression summary - The Human Protein Atlas
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein an d functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene.
Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc …
1995年1月1日 · This chapter discusses the early growth response protein (Egr) gene family and its most extensively characterized member, Egr-1, first identified as an immediate-early gene responsive to growth factors and various differentiation cues, later confirmed to be a transcriptional regulatory protein.
Frontiers | The Role of Early Growth Response 1 (EGR1) in Brain ...
2017年3月5日 · Early growth response 1 (Egr-1) regulates N-methyl-d-aspartate receptor (NMDAR)-dependent transcription of PSD-95 and α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) trafficking in hippocampal primary neurons.
Egr-1 regulates irradiation-induced autophagy through Atg4B to …
All of three Egr-1-binding sites of the Atg4B promoter were interacted with Egr-1 protein in SMMC-7721 cells . These results suggested that Atg4B is a direct transcriptional target of Egr-1 by interacting with the Atg4B promoter at Egr-1 binding sites. Figure 4. Open in a new tab. Egr-1 directly binds to Atg4B promoter. ...
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