Drosophila as a Model for Infectious Diseases - PMC
This work shows that Drosophila can be used to study the role of pathogenic proteins that modulate the immune system in a way that is independent of classical immunosignal pathways, broadening the utility of Drosophila in infectious disease research.
Vibrio cholerae Infection of Drosophila melanogaster Mimics the …
2005年9月30日 · Here we report the susceptibility of the fruit fly, Drosophila melanogaster, to oral V. cholerae infection through a process that exhibits many of the hallmarks of human disease: (i) death of the fly is dependent on the presence of cholera toxin and is preceded by rapid weight loss; (ii) flies harboring mutant alleles of either adenylyl cyclase ...
Drosophila as a Model Organism - PubMed
Drosophila melanogaster has been widely used in classical and modern genetics for more than 100 years. The history of the Drosophila model in the study of various aspects of life sciences will be summarized in this chapter. Furthermore, commonly used techniques and tools with Drosophila models will …
Animal models to study acute and chronic intestinal inflammation in ...
2015年11月10日 · Caenorhabditis elegans and Drosophila can be used as effective invertebrate models for identifying early processes involved in the initiation and progression of innate aspects of intestinal inflammation , cell signalling, epithelial barrier function, and the impact of bacterial populations on intestinal physiology [47, 95].
A Drosophila Model for Clostridium difficile Toxin CDT Reveals ...
2020年2月2日 · We created transgenic Drosophila lines expressing the catalytic subunit CDTa to investigate its interaction with host signaling pathways in vivo. When expressed in the midgut, CDTa reduces body weight and fecal output and compromises survival, suggesting severe impairment of digestive functions.
Irinotecan cause the side effects on development and adult …
2023年12月31日 · Here, we used Drosophila melanogaster (fruit fly) as in vivo model to delineate the side effects and underlying mechanisms of Irinotecan (CPT-11). The results showed that administration of CPT-11 delayed larval development, induced imbalance of male to female ratio in offspring, shortened lifespan, impaired locomotor ability, changed metabolic ...
Assessment of The Effect of Antidiarrheal Drugs and Plant
2023年11月17日 · In this study, an antidiarrheal effect induced by P. guajava is demonstrated in a D. melanogaster strain that presents a diarrheic phenotype. Fecal sampling produced by flies is monitored using a dye-supplemented food.
The interplay between intestinal bacteria and host metabolism in …
2016年3月1日 · Although the rapid transit of nutrients through the intestine that defines diarrhea is bound to be responsible for some of this, research in Drosophila has elegantly revealed pathogen impacts on host metabolism that extend beyond decreased intestinal transit time.
Human pathogenic bacteria, fungi, and viruses in Drosophila
Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila–microbe interaction studies have helped to define innate immunity pathways, and significant effort has been made lately to decipher mechanisms of microbial pathogenesis. Here we catalog 68 ...
Drosophila melanogaster, the fruit fly, has been used as an experimental model for elucidation of many novel drug delivery pathways in humans due to 70% similarity between the Drosophila and human genome, as shown by BLAST results.