Molecular Mechanisms of Colon Cancer Progression and …
In their multistep genetic model, formation of CRC occurs due to accumulation of several genetic and epigenetic alterations in key genes involved in silencing of TSGs and activation of oncogenes [10, 11, 12]. In this regard, two major pathways were defined for CRC formation.
Inducible mouse models of colon cancer for the analysis of …
2020年12月14日 · Experimental model systems that mimic key features of CRC are valuable tools for gaining better understanding of mechanisms underlying tumor initiation and progression. In addition, preclinical...
Simulation Models for Colorectal Cancer
The models simulate colorectal disease progression in a large population of individuals from birth to death. As each individual ages, there is a chance that an adenomatous polyp – a benign precursor lesion that leads to colorectal cancer – develops.
Mouse models in colon cancer, inferences, and implications
2023年6月16日 · Recent research points toward the relevance of tumor, angiogenic, and immune microenvironments in CRC progression to late-stage disease, as well as the treatment of it. This study examines important mouse models in CRC, discussing inherent strengths and weaknesses disclosed during their construction.
Colorectal cancer models overview
All three colorectal models are stochastic microsimulation models. The term "stochastic" implies that the models simulate sequences of events by drawing from distributions of probabilities or durations randomly rather than using fixed values.
Validation of a model of colon cancer progression - PubMed
A unique feature of SW480 and SW620 colon carcinoma cell lines is that they are derived from primary and secondary tumours resected from a single patient. As such, they may represent a valuable resource for examining genetic changes late in colon cancer progression. In order to verify this, both cel …
Cellular Model of Colon Cancer Progression Reveals Signatures …
2017年4月13日 · Here, we developed and comprehensively characterized a cellular model of colon cancer progression consisting of four defined derivatives of a colon cancer cell line that resulted from consecutive epithelial–mesenchymal and mesenchymal–epithelial transitions (EMT/MET) and phenotypically recapitulate the metastatic cascade.
Modeling colorectal cancer evolution | Journal of Human …
2021年5月13日 · Understanding cancer evolution provides a clue to tackle therapeutic difficulties in colorectal cancer. In this review, together with related works, we will introduce a series of our studies,...
Inducible mouse models of colon cancer for the analysis of …
In this model, the combination of p53 deficiency and AOM promotes tumor development, including growth of invasive cancers and lymph node metastasis.
Molecular Basis of Colorectal Cancer - The New England Journal of Medicine
2009年12月17日 · Colorectal cancers acquire many genetic changes, but certain signaling pathways are clearly singled out as key factors in tumor formation (Figure 2 and Table 2). 41–62 One of these changes, the...
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