CAR T cell - Wikipedia
In biology, chimeric antigen receptors (CARs)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor proteins that have been engineered to give T cells the new ability to target a specific antigen.
Chimeric Antigen Receptor T-Cell Therapy - StatPearls - NCBI Bookshelf
2022年10月3日 · Chimeric antigen receptors (CARs) are recombinant receptors for antigens that redirect the specificity and function of T lymphocytes or other immune cells in a single molecule.
An introduction to chimeric antigen receptor (CAR) T-cell ... - PubMed
Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen.
CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
2022年3月10日 · They are made by collecting T cells from the patient and re-engineering them in the laboratory to produce proteins on their surface called chimeric antigen receptors, or CARs. The CARs recognize and bind to specific proteins, or antigens, on the surface of cancer cells.
Chimeric Antigen Receptor Therapy | New England Journal of …
2018年7月4日 · Chimeric antigen receptor (CAR) T cells were recently approved by the Food and Drug Administration (FDA) and are poised to enter the practice of medicine for the treatment of leukemia and...
Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T lymphocytes to target chosen antigens. The targeting of CD19, a cell surface molecule expressed in the vast majority of leukemias and lymphomas, has been successfully ...
Chimeric antigen receptor signaling: Functional consequences …
2020年5月20日 · Chimeric antigen receptor (CAR) T cell therapy has transformed the care of refractory B cell malignancies and holds tremendous promise for many aggressive tumors. Despite overwhelming scientific, clinical, and public interest in this rapidly expanding field, fundamental inquiries into CAR T cell mechanistic functioning are still in their infancy.
From TCR fundamental research to innovative chimeric antigen receptor ...
2024年10月21日 · Engineered T cells that express chimeric antigen receptors (CARs) have transformed the treatment of haematological cancers. CARs combine the tumour-antigen-binding function of antibodies with the...
Allogeneic chimeric antigen receptor cell therapies for cancer
2 天之前 · Chimeric antigen receptor (CAR) T cells are revolutionizing cancer therapy, particularly for haematological malignancies, conferring durable and sometimes curative responses in patients with ...
Chimeric Antigen Receptor - an overview | ScienceDirect Topics
Chimeric antigen receptors (CARs) are fusion proteins where the binding site of a monoclonal antibody (Ab) is fused to intracellular signaling molecules. Upon engraftment in T cells, CARs direct their antigen-specificity toward antigens expressed on the cell surface of tumor cells.