Calcium-Channel Blockers (CCBs) - CV Pharmacology
Currently, approved calcium-channel blockers (CCBs) bind to L-type calcium channels on vascular smooth muscle, cardiac myocytes, and cardiac nodal tissue (sinoatrial and atrioventricular nodes). These channels regulate the influx of calcium into cells.
Pharmacology and mechanisms of action of calcium-channel blockers
The calcium-channel blockers represent a group of organic chemical structures that share the ability to inhibit Ca2+ entry into excitable cells. In coronary and peripheral arterial smooth muscle and the heart, inhibition of Ca2+ entry blunts the ability …
Calcium Channel Blockers - StatPearls - NCBI Bookshelf
2024年2月22日 · Identify appropriate indications for calcium channel blockers in cardiovascular and non-cardiovascular conditions. Implement evidence-based dosing strategies and monitoring protocols for patients prescribed calcium channel blockers.
Calcium Channel Blockers: Types, Uses and Side Effects - Cleveland Clinic
Calcium channel blockers are a group of medications that limit how your body uses the essential mineral calcium. Because your heart and circulatory system need calcium to function, these medications treat high blood pressure, heart rhythm problems and more.
Calcium Channel Blockers - PMC - PubMed Central (PMC)
Calcium channel blockers (CCBs) inhibit the flow of extracellular calcium through ion‐specific channels that span the cell wall. Although several types of such channels have been identified, currently available CCBs inhibit the l ‐type channels in humans.
The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium …
Use-dependent N-type calcium channel blockers are likely to be of therapeutic use in chronic pain conditions. Thus, more selective calcium channel blockers hold promise for therapeutic intervention. I. Introduction
Calcium channel blockers - Mayo Clinic
2023年8月23日 · By blocking calcium, calcium channel blockers allow blood vessels to relax and open. Some calcium channel blockers also can slow the heart rate. This can further lower blood pressure. The medicines also may be prescribed to relieve chest pain, called angina, and control an irregular heartbeat.
Calcium channel blockers: classification ... - Pharmacology Corner
Calcium channel blockers act as coronary vasodilators, producing variable and dose-dependent reductions in myocardial oxygen demand, contractility, and arterial pressure. These combined pharmacologic effects are advantageous and make these agents as effective as beta blockers in the treatment of angina pectoris.
Calcium Channel Blocker - an overview | ScienceDirect Topics
Calcium channel blockers also known as calcium antagonists are a structurally and functionally heterogeneous group of compounds that interfere with inward movement of Ca++ across the cell membranes through voltage-dependent calcium channels.
Cellular Actions and Pharmacology of the Calcium Channel Blocking Drugs
1984年8月31日 · The calcium channel blockers inhibit contractile function in the heart and vascular smooth muscle and, because the initial depolarizing currents in the sinoatrial and atrioventricular nodes are carried by calcium channels, slow the heart rate and prolong atrioventricular conduction.