Cytotoxic T-lymphocyte associated protein 4 - Wikipedia
Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses.
Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4 …
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and regulates immune homeostasis.
CTLA-4: a moving target in immunotherapy - PMC - PubMed …
Cytotoxic T Lymphocyte antigen 4 (CTLA-4) (CD152) and CD28 are homologous receptors expressed by both CD4 + and CD8 + T cells, which mediate opposing functions in T cell activation. Both receptors share a pair of ligands expressed on the surface of …
CTLA-4: a moving target in immunotherapy | Blood | American …
2018年1月4日 · Cytotoxic T-lymphocyte antigen 4 (CTLA-4) (CD152) and CD28 are homologous receptors expressed by both CD4 + and CD8 + T cells, which mediate opposing functions in T-cell activation. Both receptors share a pair of ligands expressed on the surface of …
CTLA-4: new insights into its biological function and use in …
2002年7月1日 · CTLA-4 −/− mice suffer a rampant lymphoproliferative disorder characterized by polyclonal T cell proliferation and early lethality, providing compelling support for a critical role for CTLA-4...
Molecular and Cellular Functions of CTLA-4 - PubMed
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells.
Frontiers | Current understanding of CTLA-4: from mechanism to ...
2023年7月10日 · CTLA-4 is a molecule that participates in the regulation of T-cell activity during autoimmune response, and multiple CTLA-4 single-nucleotide polymorphisms (SNPs) have been demonstrated to be closely associated with RA.
Anti-CTLA-4 nanobody as a promising approach in cancer
2024年1月8日 · Cytotoxic T lymphocyte-associated protein-4 (CTLA-4) is an essential immune molecule that plays a vital role in cell cycle modulation, regulation of T cell proliferation, and cytokine...
CTLA-4: From mechanism to autoimmune therapy - ScienceDirect
2020年3月1日 · CTLA-4 has a critical and central role in the regulation of immune responses and induction of self-tolerance. CTLA-4 controls the T-cell activation in the many ways by which is important for protection against autoimmunity.
CTLA-4: Checkpoints beyond the membrane - Cell Press
2024年2月7日 · CTLA-4 is a dimeric receptor upregulated to moderate levels on effector T cells and constitutively highly expressed on regulatory T cells (Tregs).