Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease
2019年9月25日 · Two main biologic mechanisms can lead to chronic obstructive pulmonary disease (COPD) in adulthood: abnormal lung development and an increased rate of lung-function decline with age.
Chronic Obstructive Pulmonary Disease - StatPearls - NCBI Bookshelf
2023年8月7日 · Identify the etiology, epidemiology, and pathophysiology of chronic obstructive pulmonary disease (COPD). Recall, analyze, and select appropriate history, physical, and evaluation of chronic obstructive pulmonary disease (COPD).
Pathogenesis of chronic obstructive pulmonary disease: …
2024年9月27日 · COPD=chronic obstructive pulmonary disease. In our view, the integration of a time axis in our understanding of disease pathogenesis could uncover novel opportunities for prevention or early treatment of COPD, and possibly also for prevention and treatment of the multimorbid conditions that frequently accompany COPD because they share similar ...
Mechanisms, Pathophysiology and Currently Proposed Treatments …
2021年9月26日 · Oxidative stress is the primary cause of COPD pathogenesis, triggering apoptosis, extracellular matrix remodeling, inactivation of protease inhibitors, mucus secretion, NF-κB activation, mitogen-activated protein kinase (MAPK) activation, chromatin remodeling, and pro-inflammatory gene transcription [71,74,75].
Pathology, pathogenesis, and pathophysiology | The BMJ
2006年5月18日 · Learn how cigarette smoke and inflammation cause tissue destruction, oxidative stress, and airflow obstruction in chronic obstructive pulmonary disease (COPD). Explore the cellular and molecular mechanisms, mediators, and mediators involved in the disease process.
Chronic obstructive pulmonary disease - The Lancet
2022年5月6日 · Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity, mortality, and health-care use worldwide. COPD is caused by exposure to inhaled noxious particles, notably tobacco smoke and pollutants.
Chronic obstructive pulmonary disease - Nature
2015年12月3日 · COPD is characterized by poorly reversible airway obstruction, which is confirmed by spirometry, and includes obstruction of the small airways (chronic obstructive bronchiolitis) and...
Pathogenesis of chronic obstructive pulmonary disease (COPD …
This review discusses the basic pathogenesis of COPD, with particular focus on an endogenous protective mechanism against oxidative stress via Nrf2, altered immune response of the airway inflammatory cells, exaggerated cellular senescence of the lung structural cells, and cell death with expanded inflammation.
Pathogenesis of chronic obstructive pulmonary disease - JCI
2012年8月1日 · This Review discusses the pathogenesis of COPD, with particular focus on emphysema, based on the concept that pulmonary injury involves stages of initiation (by exposure to cigarette smoke, pollutants, and infectious agents), progression, and consolidation.
Recent advances in chronic obstructive pulmonary disease pathogenesis ...
2019年12月3日 · Chronic obstructive pulmonary disease (COPD) is an often severely disabling chronic lung disease with a high prevalence of over 250 million cases worldwide. It is currently the fourth leading cause of death globally and is predicted to be the third by 2020 1.