BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
Mutaciones en el gen BRCA: el riesgo de cáncer y las pruebas …
El BRCA1 y el BRCA2 a veces se conocen como genes supresores de tumores porque cuando tienen cambios específicos, llamados variantes (o mutaciones) dañinas (o patógenas), es posible que aparezca el cáncer.
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also developed to help patients make informed decisions about their health.
Surgery to Reduce the Risk of Breast Cancer - National Cancer …
Yes. Risk-reducing (also called preventive or prophylactic) surgery can lower the risk of breast cancer in people who are at very high risk, such as women who carry a harmful mutation in a breast cancer susceptibility gene such as BRCA1, BRCA2, TP53, or PTEN.
Genetic Testing Fact Sheet - NCI - National Cancer Institute
Findlay GM, Daza RM, Martin B, et al. Accurate classification of BRCA1 variants with saturation genome editing. Nature 2018; 562(7726):217-222. [PubMed Abstract]
Genetics of Prostate Cancer (PDQ®) - NCI - National Cancer Institute
2024年6月27日 · The PPV of PSA with a biopsy threshold of 3.0 ng/mL was 48% in carriers of BRCA2 pathogenic variants, 33.3% in BRCA2 noncarriers, 37.5% in BRCA1 carriers, and 23.3% in BRCA1 noncarriers. Ninety-five percent of the men were White; therefore, the results cannot be generalized to all ethnic groups.
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
2024年4月15日 · For women in whom gene testing finds “harmful changes” in the BRCA1 or BRCA2 genes, leading medical groups recommend that they take specific actions to lower their chances of being diagnosed with or dying from breast and ovarian cancer.
Definición de gen BRCA2 - Diccionario de cáncer del NCI
Gen que da origen a una proteína que repara el ADN dañado. Las mutaciones (cambios) en el gen BRCA2 aumentan mucho el riesgo de presentar cáncer de mama y cáncer de ovario.
Breast Cancer Risk Assessment Tool: Online Calculator - NCI
Women carrying a breast-cancer-producing mutation in BRCA1 or BRCA2; Women with a previous history of invasive or in situ breast cancer (lobular carcinoma in situ or ductal carcinoma in situ) Women in certain other subgroups (See Other Risk Assessment Tools. section.)