Mouse models of colorectal cancer: Past, present and future ...
In this review, we discuss the different mouse models of CRC with their distinct advantages and disadvantages with a focus on their translational and clinical relevance. Carcinogen-induced …
Mouse models in colon cancer, inferences, and implications
2023年6月16日 · This article presents an accounting of important mouse models in colon cancer and the technology behind them, discussing inherent strengths and weaknesses revealed in …
Mutant p53 in colon cancer - PMC - PubMed Central (PMC)
Loss of wild-type p53 in intestinal tumor mouse model. APC gene mutation is a gate keeper event for colorectal cancer development that activates canonical Wnt signaling. In normal intestinal …
APC, K-ras, and p53 gene mutations in colorectal cancer patients ...
Current researches have proposed a genetic model for colorectal cancer (CRC), in which the sequential accumulation of mutations in specific cancer-related genes, including adenomatous …
Mutations in APC, Kirsten-ras, and p53—alternative genetic …
2002年7月7日 · A genetic model for colorectal cancer has been proposed in which the sequential accumulation of mutations in specific genes, including adenomatous polyposis coli (APC), …
Mouse models in colon cancer, inferences, and implications - Cell …
Recent research points toward the relevance of tumor, angiogenic, and immune microenvironments in CRC progression to late-stage disease, as well as the treatment of it. …
APC and P53 mutations synergise to create a therapeutic …
Pharmacological NOTUM inhibition is efficacious in a preclinical animal model of metastatic colon cancer. Ultimately, we asked whether small molecule inhibition of NOTUM represents a viable …
Mouse models of colorectal cancer as preclinical models - PMC
One of the most promising models for both the elucidation of the molecular events that support the formation of distant metastases of colorectal cancer and for preclinical investigations is a …
The prognostic significance of K-ras, p53, and APC mutations in ...
2005年4月11日 · Background: Accumulation of molecular alterations, including mutations in Kirsten-ras (K-ras), p53, and adenomatous polyposis coli (APC), contribute to colorectal …
The path to metastatic mouse models of colorectal cancer
2018年2月21日 · Among solid tumors, colorectal cancer (CRC) is one of the malignancies that best suits reproduction in an animal model: it evolves through a progressive set of molecular …
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