干货：九大肿瘤相关信号通路介绍-EGFR通路及靶标介绍（一）
常用的egfr-tki包括吉非替尼和厄洛替尼，是目前nsclc 患者最有效的靶向药物。但egfr-tki并非对所有患者都有效。egfr外显子 18、19或21发生突变的患者，吉非替尼有效率可高达80%。而野生型的患者基本无效。并且 egfr外显子20号突变与egfr-tki的耐药性密切相关。
ERK signalling: a master regulator of cell behaviour, life and fate
2020年6月23日 · Recent work showed that glutamine dependency of EGFR-mutant glioblastoma was caused by transcriptional induction of glutamate dehydrogenase 1 (GDH1) through ERK phosphorylation of ELK1 (ref....
MAPK/ERK pathway - Wikipedia
Key components of the MAPK/ERK pathway. "P" represents phosphate, which communicates the signal. Top, epidermal growth factor (EGF) binds to the EGF receptor (EGFR) in the cell membrane, starting the cascade of signals. Further downstream, phosphate signal activates MAPK (also known as ERK).
生物医药靶点赛道：ERK 1/2 通路-EGFR（1） - 雪球
2022年8月17日 · 本系列将主要介绍第一条由生长因子介导的erk 1/2 通路的赛道情况，涵盖蛋白 ras、raf、mek 和 erk，其中任何一个蛋白的异常都有可能诱导肿瘤的发生和增殖，故皆已成为各类创新药靶向的热门靶标。
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
Here, we will review the activation mechanisms by which the EGFR activates the ERK MAPK, AKT-PI3K, and PLC-γ1-PKC pathways, focusing on the molecular interactions between each protein in the pathways . We will focus on the important domains and amino acids that help propagate the signaling pathways.
A comprehensive pathway map of epidermal growth factor …
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated ...
Synergistic anticancer effect by targeting CDK2 and EGFR-ERK
2024年1月1日 · The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell survival, growth, and proliferation. Aberrant activation of this pathway is a common mechanism in various cancers. Here, we report that CDK2 is a novel regulator of the ERK pathway via USP37 deubiquitinase (DUB).
Piezo1 activates noncanonical EGFR endocytosis and signaling
2023年9月27日 · EGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. While EGF ligand and mechanical inputs can activate EGFR-ERK signaling, the molecules linking mechanical force to this axis have remained mysterious.
The Epidermal Growth Factor Receptor System in Skin Repair …
2008年6月1日 · The EGFR–ERK pathway plays a crucial role in mediating both the pro-survival and proliferative programs of keratinocytes. Indeed, human epidermal keratinocytes maintain high steady-state levels of ERK activity essentially via their autocrine production of EGFR ligands (Iordanov et al., 2002).
Feedback regulation of EGFR signalling: decision making by early …
2011年1月21日 · EGFR signalling (through ERK) triggers the degradation of YAN, thereby de-repressing miR-7 and promoting a photoreceptor fate.