SOS response - Wikipedia
The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The system involves the RecA protein (Rad51 in eukaryotes). The RecA protein, stimulated by single-stranded DNA, is involved in the inactivation of the repressor of SOS response genes thereby inducing the response ...
The SOS system: A complex and tightly regulated response to …
We focused on the molecular basis of the SOS response induction and progression, the role of individual proteins and factors involved in the SOS response as well as consequences of its induction for bacterial genome stability.
Sending out an SOS - the bacterial DNA damage response
Miroslav Radman used the distress signal “SOS” to define how bacterial cells sense genome instability, while studying DNA damage and replication blockages in Escherichia coli (Radman, 1974). This phenomenon triggers a pathway of physiological responses to deal with these adverse conditions, mainly DNA damage repair and/or tolerance and mutagenesis.
基础医学院冯钰/周春课题组《PNAS》发文解析细菌SOS反应的调 …
2023年1月4日，浙江大学基础医学院冯钰和公共卫生学院周春团队联合攻关，在《PNAS》发表了题为“Structural basis for regulation of SOS response in bacteria”的研究论文，该研究首次解析了细菌SOS反应核心组分RecA蛋白与DinI、...
细菌DNA损伤修复的诱导、调控及结局的研究进展
2022年2月20日 · DNA损伤修复（SOS反应）是细菌适应环境、抵抗外界压力和修复自身损伤的重要机制。 为了解SOS反应的过程，全面揭示细菌生存机制，本研究对DNA损伤修复的过程、调节及适应性变化进行文献综述。 结果表明，内源和外源的诸多压力都可以激活SOS反应，抗生素是激活该反应的主要因素。 RecA在感知外界压力和系统启动过程中发挥重要作用，也是整个反应调控的重要靶点。 LexA作为阻遏蛋白是整个反应的抑制剂，SOS反应启动后，其释放下游一系列 …
Structural basis for regulation of SOS response in bacteria
Our structures explain five decades of research on bacterial SOS response and potentially will aid rational drug design to combat antimicrobial resistance. In response to DNA damage, bacterial RecA protein forms filaments with the assistance of DinI protein.
DNA Damage Repair and Bacterial Pathogens - PMC - PubMed …
The SOS response regulates DNA repair and damage tolerance genes in many bacterial species. This article highlights the bacterial SOS response and its significance in bacterial adaptation and pathogenesis, as well as DNA damage responses provoked by bacterial pathogens in the mammalian host.
SOS-independent bacterial DNA damage responses: diverse …
2023年6月1日 · In this review, we discuss recent insights gained into bacterial DDRs, with a focus on three DDRs that are activated independent of the SOS response. We first briefly describe each DDR pathway (PafBC response, DriD response, and adaptive response to methylation damage).
SOS Repair - SOS Response in Bacteria - Biology Notes Online
2024年6月1日 · The SOS response is a critical cellular mechanism in E. coli and various other bacteria, activated in response to significant DNA damage. This response is orchestrated primarily by two central proteins: LexA and RecA.
After 30 Years of Study, the Bacterial SOS Response Still …
2005年7月12日 · The bacterial SOS response kicks in when bacteria experience DNA damage, and helps the organisms correct and survive DNA damage events. This primer provides a foundation for understanding these events.