Regulation of RIP1 kinase signalling at the crossroads of
2013年10月16日 · Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream regulator that controls inflammatory signalling as well as the activation of multiple cell death...
RIP1, a kinase on the crossroads of a cell's decision to live or die
2007年2月15日 · RIP1 is a crucial adaptor kinase on the crossroad of these stress-induced signalling pathways and a cell's decision to live or die. Following different upstream signals, particular...
Receptor-interacting protein (RIP) kinase family - PMC
2010年4月12日 · RIP1 contains a C-terminal death domain, through which RIP1 can be recruited to signaling complexes that initiate different pathways. RIP2 bears a caspase activation and recruitment domain (CARD). RIP3 has a C-terminus that is unique among all known protein domains. However, a RIP homotypic interaction motif (RHIM) found in the intermediate ...
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
2020年7月15日 · The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have...
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic …
A type I membrane receptor that contains an intracellular death domain that, when activated, can recruit receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and TRADD to mediate inflammatory and pro-survival functions through the NF-κB pathway, as well as cell death mediated by RIPK1 kinase activity.
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic ... - PubMed
2020年8月20日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have dem …
RIP1 inhibition blocks inflammatory diseases but not tumor …
2019年5月17日 · The kinase RIP1 acts in multiple signaling pathways to regulate inflammatory responses and it can trigger both apoptosis and necroptosis. Its kinase activity has been implicated in a range of inflammatory, neurodegenerative, and oncogenic diseases.
Role of Receptor Interacting Protein (RIP) kinases in cancer
2021年11月18日 · Each RIP family member contains a conserved kinase domain and other domains that determine the specific kinase function through protein–protein interactions. RIP1 and RIP3 are best known for their critical roles in necroptosis, programmed necrosis and a non-apoptotic inflammatory cell death process.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1 ...
2017年2月2日 · The availability of necrostatin-1, a specific inhibitor of RIP1 kinase, made it possible to dissect the distinct functional domains of RIP1. Recent genome-wide siRNA screens have identified multiple players of necroptosis that may interact with and/or regulate RIP1 kinase and mediate the signaling pathway and execution of necroptosis.
RIPK1 in the inflammatory response and sepsis: Recent advances, …
RIPK1 comprises the N-terminal kinase domain, the C-terminal death domain that mediates death signaling, the bridging intermediate domain, and the RIP homotypic interaction motif (RHIM).