IFNγ-induction of TH1-like regulatory T cells controls antiviral ...
2023年3月16日 · T H 1 polarization of CD4 + T conv cells is induced by IL12, whereas IFNγ has a role in T H 1 priming via induction of IL12 receptor β2 (IL12Rβ2) and IL18Rα 15. Because …
IFNγ signaling in cytotoxic T cells restricts anti-tumor ...
2023年1月19日 · We report that expression of the IFNγ receptor β chain (IFNγR2) in CD8 T cells negatively correlates with clinical responsiveness to checkpoint blockade in metastatic …
Interferon-γ: teammate or opponent in the tumour ... - Nature
2021年6月21日 · This co-recruitment of IFNGR1 and STAT1 to the immunological synapse creates a ‘T H 1 cell readiness’ upon TCR stimulation and ‘primes’ the cells to quickly polarize …
IFNγ-induction of TH1-like regulatory T cells controls antiviral ...
T H 2-like Ifngr1-deficient T reg cells were unable to limit the antiviral T cell response and CD8 + T cell effector memory (T EM) and central memory (T CM) formation. Our study uncovers a …
IFNγ-induction of TH1-like regulatory T cells controls antiviral ...
T H 1-like T reg cells limited CD8 + T cell effector function, proliferation and memory formation during acute and chronic infection. These findings provide fundamental insights into how T reg …
Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 ...
2022年11月1日 · Pharmacological mIDH1 inhibition enhanced CD8 + T cell recruitment and expression of IFN-γ and TET2-dependent IFNγR genes in tumor cells, while deficiency of CD8 …
Abstract 5308: Ifngr1 signaling on tumor-specific CD4 T cells is ...
2024年3月22日 · CD4 T cells direct tumor antigen recognition by tumor-associated macrophages and host interferon-gamma receptor (Ifngr1) signaling. Here, we demonstrate that CD4 T cells …
Interferons limit autoantigen-specific CD8+ T-cell ... - Cell Press
Sensitivity to IL-2 resulting in greater expansion of CD8 + T cells, which we observed in Ifngr1-mutant T cells, is a phenotype that may be explained at least in part by low SOCS1 levels in T …
JCI Insight - The IFN-γ receptor promotes immune dysregulation …
2022年9月8日 · Using coculture and mixed bone marrow chimeric mouse experiments, we demonstrated a cell-intrinsic contribution of IFNGR1 to SAVI mouse T cell survival. Thus, our …
Ligand-induced IFNGR1 down-regulation calibrates myeloid cell …
2019年10月4日 · Ligand-induced reductions in IFNGR1 altered myeloid cell sensitivity to IFNγ, blunting activation of STAT1 and 3. Our data, thus, reveal a mechanism by which IFNGR1 …