DNA methylation - Wikipedia
In plants and other organisms, DNA methylation is found in three different sequence contexts: CG (or CpG), CHG or CHH (where H correspond to A, T or C). In mammals however, DNA methylation is almost exclusively found in CpG dinucleotides, with the cytosines on both strands being usually methylated.
DNA Methylation and Its Basic Function
2012年7月11日 · In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine.
The Role of Methylation in Gene Expression - Nature
Today, researchers know that DNA methylation occurs at the cytosine bases of eukaryotic DNA, which are converted to 5-methylcytosine by DNA methyltransferase (DNMT) enzymes.
The Curious Chemical Biology of Cytosine: Deamination, Methylation …
Cytosine methylation or oxidation refines the genome by tailoring a gene program to a given cell lineage or altering gene expression in the face of environmental changes. Finally, multiple DNA-modifying pathways appear to collaborate to carry out cytosine demethylation, helping to establish a totipotent state in cells otherwise marked by ...
Epigenetics of Modified DNA Bases: 5-Methylcytosine and Beyond
Modification of DNA base is one of the main epigenetic mechanisms which regulate gene expression in both plants and animals. DNA methylation indicates attachment of a methyl (CH 3) group at 5′-carbon of pyrimidine ring of cytosine nucleotide.
DNA Methylation: Genomewide Distribution, Regulatory …
Cytosine is referred to as the fifth DNA base, and cytosine residue methylation is the most common DNA modification in mammalian cells. Cytosine residues in CpG dinucleotides are most often subject to methylation.
DNA methylation and its basic function - PubMed
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of tra ….
5-methylcytosine turnover: Mechanisms and therapeutic …
DNA methylation at the fifth position of cytosine (5mC) is one of the most studied epigenetic mechanisms essential for the control of gene expression and for many other biological processes including genomic imprinting, X chromosome inactivation and genome stability.
The interaction between cytosine methylation and processes of …
2017年7月7日 · Cytosine methylation involves the covalent attachment of a methyl group to the fifth atom of the carbon ring of a cytosine, forming molecules known as 5-methylcytosine (5mC) . Methylation has important functions within a cell, influencing development , gene expression and silencing , as well as being implicated in carcinogenesis .
The DNA methyltransferase family: a versatile toolkit for ... - Nature
2017年10月16日 · The DNA methyltransferases (DNMTs) are a conserved family of cytosine methylases with a key role in epigenetic regulation. DNMT activity is highly regulated. Key regulatory mechanisms include...