Development of pathophysiologically relevant models of sickle cell ...
2024年2月27日 · In this study, we present the generation of erythroid progenitor lines with sickle cell disease and β-thalassemia mutation using CRISPR/Cas9. The disease cellular models exhibit similar ...
Cell models for Alzheimer’s and Parkinson’s disease: At the …
2022年5月1日 · To transform a cell culture of neuron-like cells and non-neuron-like cells into a cellular model of AD or PD, cells must be exposed to specific neurotoxins to induce the pathogenesis of the disease as
Human disease models in drug development - Nature
2023年5月11日 · Human disease models can help unravel disease mechanisms, including for infectious and genetic diseases and cancer. Using appropriate human disease models in the drug development process...
Modelling metabolic diseases and drug response using stem cells …
2022年9月7日 · With the development of reproducible, complex and functional human stem cell-derived metabolic cell types and organoids, advances have been made to use these models for testing drug toxicity,...
Characterization and application of a disease-cell model for a ...
Disease-cell models that recapitulate specific molecular phenotypes are essential for the investigation of molecular pathogenesis of neurodegenerative diseases including lysosomal storage diseases (LSDs) with predominant neurological manifestations. Herein we report the development and characterizat …
Induced pluripotent stem cells in disease modelling and drug …
Since the first description of diseased iPSCs, models have advanced from differentiated 2D cultures of single lineage cells reporting cellular-level outputs to increasingly complex 3D organoids and in vivo chimaeras to now incorporate perturbed cell–tissue and tissue–organ level interactions into disease models.
ISMI-VAE: A deep learning model for classifying disease cells …
2024年6月1日 · We proposed the model ISMI-VAE for integrating SNV data and gene expression data and classifying disease cells. ISMI-VAE constructs a latent variable model to describe the distribution of data and uses a neural network model to integrate multimodal data into a low-dimensional feature space and to predict disease cells.
Characterization and application of a disease-cell model for a ...
2014年2月1日 · A disease-cell model for globoid-cell leukodystrophy (GLD) is described. • From brain specimens of GLD mouse model, the 145M-Twi cell line was established. • The 145M-Twi cells revealed molecular aspects of the neuropathogenesis of GLD. • The 145M-Twi cells are potential research tools for drug discovery screens.
Disease Modeling, Disease Model Systems - Molecular Devices
Disease modeling is a tool for understanding diseases and developing potential therapies that use 3D cell structures for modeling tumors, organs, and tissue to accelerate translational research.
Disease Modelling with Cells - EuroStemCell
How are stem cells used to model disease in the laboratory? This 3-minute animation gives a clear, simple and visually appealing explanation of what disease modelling is, why it is useful and how it is done.