TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives …
2019年10月10日 · We present a new signaling mechanism for macrophage lipid accumulation in which agLDL (aggregated LDL) is involved in activation of TLR4 (Toll-like receptor 4), resulting in local actin polymerization, lysosome exocytosis, and generation of a low pH environment.
Amine headgroups in ionizable lipids drive immune responses to lipid …
2024年10月3日 · Here we show that the amine headgroup of the ionizable lipid dictates the LNP immune response through its interactions with the receptors TLR4 and CD1d as well as lipid rafts in the cell...
Alarmin-loaded extracellular lipid droplets induce airway …
2024年10月3日 · Rao et al. show that ILC2s release HMGB1-loaded lipid droplets to induce neutrophil infiltration into the airway, demonstrating the crucial functions of extracellular lipid droplets in driving the pathogenic responses of ILC2s and allergic inflammation.
TREM2 regulates microglial lipid droplet formation and represses …
2024年1月1日 · Knockdown of TREM2 results in increased lipid synthesis (PLIN2, SOAT1) and decreased cholesterol clearance and lipid hydrolysis (LIPA, ApoE, ABCA1, NECH1, and NPC2), further impacting microglial phenotypes.
Role of TLR4 in the induction of inflammatory changes in …
2020年5月13日 · In our study, palmitate stimulation with 200 μM decreased relative lipid content and inhibited adipogenesis in WT EMSC Ad but failed to induce impairment in Tlr4 −/-EMSC Ad suggesting a suppression of lipid homoeostasis in mature adipocytes.
The upregulation of Annexin A2 by TLR4 pathway facilitates lipid ...
2024年1月6日 · Autophagic degradation of lipid droplets, termed lipophagy, plays a pivotal role in liver lipid catabolism, and the amelioration of NAFLD (29,109,982). During the development of NAFLD, the autophagic flux is compromised, partially contributing to the aberrant increase in hepatic lipid accumulation [5].
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives ... - PubMed
Using bone marrow transplantation of LDL receptor knockout mice with TLR4 knockout bone marrow, we show that deficiency of TLR4 protects macrophages from lipid accumulation during atherosclerosis. Finally, we demonstrate that macrophages in vivo form an extracellular compartment and exocytose lysosome contents similar to that observed in vitro ...
Ornithine lipid is a partial TLR4 agonist and NLRP3 activator - Cell …
2024年10月22日 · Pizzuto et al. reveal the dual role of the bacterial ionizable lipid, ornithine lipid (OL), in modulating immune responses via TLR4 and NLRP3. This study clarifies conflicting reports on OL inflammatory effects, identifying key receptors and suggesting mechanisms for OL-mediated pathogenicity in gram-negative and gram-positive bacteria.
Dynamics and regulation of lipid droplet formation in ...
2012年4月1日 · In this report we show that LPS-induced TLR4 activation in microglia is accompanied by marked changes in intracellular lipid droplet (LD) status as manifested by an increase in the number and volume of LDs in the cells.
TLR4 promotes smooth muscle cell-derived foam cells formation …
2024年10月25日 · Consistently, TLR4 knockout significantly suppressed macropinocytosis and lipid droplets accumulation in VSMCs. Taken together, our findings suggest a critical role of TLR4/Syk signaling in promoting receptor-independent macropinocytosis leading to VSMC-derived foam cells formation.