Ferroptosis: mechanisms, biology and role in disease
2021年1月25日 — In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumour...
Ferroptosis: past, present and future - Cell Death & Disease
2020年2月3日 — Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. Activating or blocking the ferroptosis pathway to alleviate the progression of the disease, which provides...
The cell biology of ferroptosis
2024年2月16日 — Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms mediating the...
Ferroptosis: mechanisms, biology and role in disease - PubMed
In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumour suppression and immune surveillance, and its pathological roles, together with …
Ferroptosis: principles and significance in health and disease
2024年6月6日 — This review summarizes the fundamental molecular mechanisms and regulatory pathways underlying ferroptosis, including both GPX4-dependent and -independent antioxidant mechanisms. Additionally, we examine the involvement of ferroptosis in various pathological conditions, including cancer, neurodegenerative diseases, sepsis, ischemia ...
Ferroptosis: molecular mechanisms and health implications
Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.
Ferroptosis: mechanisms and links with diseases - PMC
Ferroptosis is a newly identified iron-dependent cell death that is different from other cell death forms, including apoptosis and necrosis. The program involves three primary metabolisms involving thiol, lipid, and iron, leading to an iron-dependent generation of lipid peroxidation and, ultimately, cell death.
Signaling pathways and defense mechanisms of ferroptosis
2021年6月6日 — Ferroptosis is an oxidative cell death that can be controlled at multiple levels. Briefly, the production of ROS for ferroptosis can be initiated by iron-dependent Fenton reactions, mitochondrial dysfunction, or increased activity by the NOX family. The level of intracellular iron is further affected by various iron storage or exporter proteins.
Ferroptosis: A flexible constellation of related ... - Cell Press
2023年4月6日 — We propose that there is no universal ferroptosis pathway that can be defined to the level of specific individual metabolites and proteins. Instead, we propose new ways to think about ferroptosis as a highly flexible mechanism involving a constellation of …
KEGG PATHWAY: Ferroptosis - Homo sapiens (human)
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells.