Src family kinases Fyn and Lyn are constitutively activated ... - Nature
2017年4月3日 · Our data identify Fyn and Lyn as important factors that promote pDC responses, describe the mechanisms involved and highlight a tonic SFK-mediated signalling that precedes pathogen encounter ...
LYN kinase programs stromal fibroblasts to facilitate leukemic …
2023年3月10日 · Here we provide mechanistic evidence that LYN regulates the polarization of stromal fibroblasts to support leukemic progression. LYN is overexpressed in fibroblasts of lymph nodes of CLL...
Engagement of the B-cell antigen receptor activates STAT through Lyn …
2006年12月4日 · The PTK Lyn, a member of the Src family, plays a central role in initiating B-cell signaling process by phosphorylating immunoreceptor tyrosine activation in the BCR complex or immunoreceptor ...
LINC00926 promotes progression of renal cell carcinoma via …
2023年12月1日 · In our study, the results of function experiments (Fig. 4, Fig. 6) showed that LINC00926 inhibited the ubiquitination of Lyn, which enhanced the phosphorylation of STAT1 and downstream related genes in RCC cells. Moreover, our finding indicated that LINC00926 promoted JAK2-STAT1 signal pathway and PD-L1 surface expression.
Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its …
Lyn is a member of the Src family of intracellular membrane-associated tyrosine kinases. While the N terminus of each member is unique, this family shares significant homology in the kinase domain, as well as the SH2/SH3 protein interaction domains.
STING Negatively Regulates Double-Stranded DNA-Activated JAK1-STAT1 …
2015年5月5日 · The data presented here address a negative role of STING in regulating the activation of JAK1-STAT1 signaling directly triggered by dsDNA. dsDNA can directly activate the JAK1-STAT1 signaling via Lyn, whereas STING inhibits …
Identification of Potential Candidate Genes of Oral Cancer in …
2019年2月21日 · Overall, we utilized bioinformatical methods to identify IL6, STAT1, LYN, BDNF, C3, CD274, PDCD1LG2, and CXCL10 as potential candidate genes that might facilitate the prevention and treatment of oral squamous cell carcinoma (OSCC), the most common type of head and neck squamous cell carcinoma (HNSCC).
Interaction between DC-SIGN and WNV-E attenuates STAT1 …
Impaired STAT1-dependent downregulation of TLR3 responses were further shown in virus exposed aged macrophages leading to continuous detrimental TLR3 activation (Kong et al., 2008). In summary ...
PKC , c-Src, JAK1, or STAT1. An immunocomplex ki-nase assay showed that both IFN- and TPA activated c-Src and Lyn activities and that these effects were in-hibited by staurosporine and herbimycin. Thus, in NCI-H292 epithelial cells, IFN- activates PLC- 2 via an up-stream tyrosine kinase to induce activation of PKC-
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EngagementoftheB …
phosphorylation of STAT1, 3 and 5.DT40 cells were transfected with the Lyn kinase-inactive mutant, LynK275R, or with empty vector pcDNA3, as a negative control, were stimulated with M4 as