From August 8, 2018, to January 14, 2020, we vaccinated 265,183 participants. Of these vaccinees, 102,515 were monitored on days 0, 3, and 21 for safety. Among the contacts and contacts-of ...

Worldwide, approximately 2 million children younger than 15 years of age are infected with multidrug-resistant (MDR) Mycobacterium tuberculosis, with MDR tuberculosis developing in approximately ...

Prevention of drug-resistant tuberculosis is a global health priority. However, trials evaluating the effectiveness of treating Mycobacterium tuberculosis infection among contacts of persons with ...

The Sepsis-1, Sepsis-2, and Sepsis-3 definitions are for adult sepsis. The IPCC (International Pediatric Sepsis Consensus Conference) and Phoenix definitions are for pediatric sepsis. ARDS denotes ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

A blast injury is physical trauma caused by the rapid pressure wave and associated fragments generated by an explosion. 1,2 The resulting blast wave compresses air within open and enclosed spaces ...

Dr. Kathleen M. McFadden (Medicine): A 22-year-old woman was transferred to this hospital in the summer before the coronavirus disease 2019 pandemic because of headache, fever, and respiratory ...

Dr. James Q. Zhou (Medicine): A 56-year-old woman with metabolic dysfunction–associated steatohepatitis and cirrhosis was admitted to this hospital because of end-stage liver disease. The ...

Xalnesiran, a small interfering RNA molecule that targets a conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an ...

Standard treatment for multibacillary leprosy is multidrug therapy consisting of dapsone, rifampicin, and clofazimine, with a recommended treatment duration of 12 months. 4 Challenges include ...

Dr. Vandana L. Madhavan: A 30-month-old boy was admitted to this hospital for the third time in 4 weeks because of recurrent fever. The patient had been well until 4 weeks before the current ...

Shown is a maximum-likelihood phylogenetic tree for 1523 V. cholerae isolates, including 17 recently obtained highly drug-resistant isolates. Blue arrows indicate the three genomic waves of the ...