Brandon Aiyuk went down with a right knee injury in Sunday's 28-18 loss to the Kansas City Chiefs that coach Kyle Shanahan ...

The San Francisco 49ers sustained a season-ending knee injury in their 28-18 loss to the Kansas City Chiefs on Sunday, tests ...

Just 50 days after Ricky Pearsall was shot in an attempted armed robbery in San Francisco, the 49ers' first-round pick made ...

Ricky Pearsall, Jaylen Warren, and Drake Maye headline the biggest fantasy football targets on the Week 8 waiver wire.

The San Francisco 49ers were already reeling from Monday's bad news that wide receiver Brandon Aiyuk was out for the season ...

The 49ers' fear over Brandon Aiyuk's knee injury came to fruition. The star wide receiver has suffered an ACL tear, FOX ...

San Francisco 49ers rookie Ricky Pearsall made his NFL debut on Sunday, Oct. 20, two months after he was shot in the chest ...

San Francisco 49ers wide receiver Brandon Aiyuk suffered a major setback with an injury during a key game. Fans are eagerly ...

The San Francisco 49ers lost standout receivers Brandon Aiyuk and Deebo Samuel during Sunday's 28-18 loss to the visiting ...