In vitro, inavolisib induced the degradation of mutated PI3K catalytic alpha subunit P110α (encoded by the PIK3CA gene), inhibited phosphorylation of the downstream target AKT, reduced cellular ...

EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K. Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K. IRR Chemistry Hub, Institute ...

The latest World Economic Outlook released by the International Monetary Fund (IMF) has some good tidings, and some ominous assessments. The good news — that largely pertains to the short term ...

BRAK promotes tomato seedling growth, fruit yield and defense against B. cinerea. BRAK interacts with the phytosulfokine (PSK) receptor PSKR1, and BRAK-regulated growth and defense is related to the ...

The International Monetary Fund raised its growth forecast for the US, projecting the world's largest economy would expand by 2.8% this year instead of the 2.6% it predicted in July. In its latest ...

The semaglutide injectables, Ozempic and Wegovy, have been the centre of attention since they launched due to their stronger metabolic effects both on T2D and obesity patients. Credit: fcm82 / ...

VIBRANT ECONOMY. The skyline and business district of Bonifacio Global City in Taguig City are photographed on a clear afternoon on Oct. 4, 2024. The Philippines' economic growth is expected to reach ...

Membrane proteins are sorted to the plasma membrane (PM) via Golgi-dependent trafficking. However, our recent studies challenged the essentiality of Golgi in the biogenesis of specific transporters.

Rubana Huq’s garment factory is a constant cacophony of hissing steam irons, swooshing fans and snipping scissors. In the vast industrial facility near Dhaka, hundreds of women guide pieces of ...