Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

I don't necessarily think about normal stem cells dying when colon cancer is starting,” Sethi commented. To understand the sequence of these early events, the researchers did a timed deletion of one ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

The use of intestinal organoid cultures is a foundation for most of the studies in the lab. These cultures are derived from stem cells isolated from human intestinal tissue. The stem cells are ...

When Anne Maldzinski underwent a blood stem-cell transplant to cure her cancer, the procedure triggered a life-threatening ...