Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

Huch’s pancreatic organoids are now a promising avenue for disease modeling and generating precision medicines to treat ...

I don't necessarily think about normal stem cells dying when colon cancer is starting,” Sethi commented. To understand the sequence of these early events, the researchers did a timed deletion of one ...

When they do not function as intended, stem cells can result in a number of health conditions including inflammatory bowel disease (IBD) and colorectal (bowel) cancer, where they continue to ...

When they do not function as intended, stem cells can result in a number of health conditions including inflammatory bowel disease (IBD) and colorectal (bowel) cancer, where they continue to ...

and translating this knowledge into novel therapeutic approaches to treat diseases of the intestine such as IBD and colorectal cancer. In addition to mechanistic studies, his lab developed novel organ ...

The use of intestinal organoid cultures is a foundation for most of the studies in the lab. These cultures are derived from stem cells isolated from human intestinal tissue. The stem cells are ...