Phosphorylation is the enzymatic process through which a phosphate group is added via an ester bond, generally by a kinase, to either a small molecule or a protein. Protein phosphorylation is ...

Reference: “PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance” by Pragya Parashara, Bethan Medina-Pritchard, Maria Alba Abad, Paula Sotelo-Parrilla, Reshma ...

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As the cell’s clean-up crew attempts to remove the clumps, a leading theory suggests that the abnormal tau induces phosphorylation in additional proteins leading to a cascade of neurodegeneration.

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Goodman and Bellen place this subpar response to oxidative stress upstream in the AD cascade, when tau phosphorylation begins and ROS start to accumulate. Complicating this scenario, AD risk factors, ...

(Most of these details come from Fred Beckey’s seminal “Cascade Alpine Guide: Climbing and High Routes, Vol. 2: Stevens Pass to Rainy Pass,” one of the Bibles of the climbing set. Full of ...

Strengths include the combination of cell and whole-animal (Drosophila) based studies. However, the evidence supporting the conclusions is incomplete and additional experimentation (which could ...

College of Chemical and Materials Engineering, Xuchang University, Xuchang 461000, PR China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, ...

Objective Zanubrutinib is a second-generation Bruton’s tyrosine kinase inhibitor that has been approved for the treatment of several B cell malignancies. The aim of this study was to evaluate adverse ...