Mechanistically, the calcium-activated protein ALIX transduces lysosomal damage signals to SG formation by controlling eIF2α phosphorylation after sensing calcium leakage. ALIX enhances eIF2α ...

Phosphorylation is the enzymatic process through which a phosphate group is added via an ester bond, generally by a kinase, to either a small molecule or a protein. Protein phosphorylation is ...

Kinases and phosphatases, which remove phosphate groups, are involved in nearly all signal transduction processes, often with cascades of phosphorylation events. How obesity causes cardiac ...

In vitro, inavolisib induced the degradation of mutated PI3K catalytic alpha subunit P110α (encoded by the PIK3CA gene), ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

This Virtual Special Issue will offer a computational journey through the field of nucleic acid processing and editing. Submit your manuscript for consideration by November 30th, 2024. This Virtual ...