The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...

An estimated 20 percent of adults in the US experience chronic pain. 1 To help patients manage their condition, clinicians have employed one main type of pain-relieving drug: opioids. With their ...

This study uses a wide range of approaches to identify acylation as a key regulator of Orai1 channel activation and calcium entry. The results show a novel role for Orai1 acylation in promoting ...

Overexpression and increased transcriptional activity of NFAT isoforms has been detected in various human solid tumours and cell lines, as well as haematological malignancies. This leads to the ...