The mechanisms by which cell polarity is translated into segregation ... evidence indicates that spindle positioning is mediated by microtubule depolymerization and dynein function, as well ...

Johanna Höög and colleagues acquired serial section images of a cell and combined these into a 3D reconstruction. The resolution of the reconstruction was such that microtubule polarity ...

and disrupted neuronal polarity can cause disease. For example the mis-localization of the microtubule-associated protein, tau, and of the transmembrane protein beta-amyloid is thought to contribute ...