In this 6-week, double-blind trial, 585 patients were randomized to losartan/ hydrochlorothiazide or losartan as monotherapy and titrated as needed at 2-week intervals to reach goal blood pressure ...

The CASE-J trial enrolled 4728 patients, with a mean age of 63.8 years and a mean BMI of 24.6 kg/m 2, who were randomly assigned to either candesartan- or amlodipine-based treatment regimens.