After two years of fundraising, the Foundation for Lincoln Public Schools officially ended its $33 million Fielding Dreams campaign to fund the completion of new athletic complexes at Lincoln’s ...

Finally, the monoclonal antibody 15C1 that neutralizes LPS-induced signalling in the presence or absence of MD-2 by a novel Fc receptor-mediated mechanism has been reported 87. Figure 5 ...

This important study demonstrated that ablation of astrocytes in the lumbar spinal cord not only reduced neuropathic pain but also caused microglia activation. The findings presented add considerable ...

TBK1 subsequently phosphorylates and activates IRF3 (interferon regulatory factor 3). The activated IRF3 enters the nucleus and initiates the release of type I interferons. Additionally, STING ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Obesity has emerged as a prominent global public health concern, leading to the development of numerous metabolic disorders such as cardiovascular diseases, type−2 diabetes mellitus (T2DM), sleep ...

Moreover, the overexpression of ICP34.5 effectively inhibited lipopolysaccharide (LPS) -induced NF-κB pathway activation by inhibiting p65 entry into the nucleus (Figure 2B-C). Collectively, these ...

Toll-like receptors (TLRs) recognise pathogen-associated molecular patterns (PAMPs) to detect the presence of pathogens. In addition to their role in innate immunity, TLRs also play a major role in ...